Center for Surgery in Older Adults »  Collaborators »  Vascular Surgery »  Marlene Grenon, M.D., C.M.

Marlene Grenon, M.D., C.M.

Associate Professor
Division of Vascular and Endovascular Surgery

Contact Information

Division of Vascular and Endovascular Surgery, UCSF
400 Parnassus Avenue, A-501
San Francisco, CA 94143-0957
Phone: (415) 353-2357
Fax: (415) 353-2669
Marlene.Grenon@ucsf.edu
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  • 1998, International Space University, Diploma in Space Sciences
  • 1995-00, McGill University, Doctorate of Medicine and Masters of Surgery
  • 2002-04, Harvard Medical School, Master in Medical Sciences - Clinical Investigations
  • 2000-02, Dalhousie University, Resident, Cardiac Surgery
  • 2002-06, McGill University, Resident, Cardiac Surgery
  • 2006-07, McGill University, Chief Resident, Cardiac Surgery
  • 2007-09, University of British Columbia, Fellow, Vascular Surgery
  • 2009-10, Arizona Heart Institute, Fellow, Vascular and Endovascular Surgery
  • 2002-04, Harvard Medical School & Massachussetts Institute of Technology, Research Fellow, Cardiovascular Space Medicine
  • Abdominal Aortic Aneurysm
  • Carotid Artery Disease
  • Chronic Venous Insufficiency
  • Complex Limb Revascularization
  • Critical Limb Ischemia
  • Deep Vein Thrombosis
  • Diabetic Vascular Disease
  • Dialysis Access
  • Endovascular Aneurysm Repair
  • Mesenteric Artery Disease
  • Peripheral Artery Disease
  • Thoracic Aortic Aneurysm
  • Varicose Veins
  • Vascular Malformations

Dr. Marlene Grenon was born in Quebec, Canada. She obtained a diploma in space sciences from the International Space University (ISU) in 1998. She graduated from McGill Medical School in 2000 and obtained a Masters' degree from the Scholars in Clinical Science Program of Harvard Medical School along with a post-doctoral fellowship in cardiovascular space medicine and endocrinology from Brigham and Women's Hospital and the Massachusetts Institute of Technology (MIT) in 2004. She then completed training in cardiac surgery at McGill University in 2007, vascular surgery at the University of British Columbia in 2009 and endovascular surgery at the Arizona Heart Institute in 2010. She is a fellow from the Royal College of Physicians and Surgeons of Canada (RCPSC) and maintains a Certificate of Specialist in both cardiac and vascular surgery from RCPSC.

Dr. Grenon is presently an Associate Professor in the Department of Surgery at UCSF, a Staff surgeon at the VAMC San Francisco and an Adjunct Faculty at the International Space University. She is a member of many professional organizations and has been an invited lecturer at several regional, national and international meetings and conferences. She is the recipient of several awards for research and was one of the finalists in the 2009 Canadian Astronaut selection.

My current research program encompasses two areas:

Lifestyle modifications for peripheral arterial disease (PAD)

It is well known that lifestyle issues including nutrition, physical activity, and stress have a high impact on disease development and readaptation in patients with cardiovascular disease. The evidence for how nutrition, physical activity, and stress affect patients with PAD is less clear. In my research program, we are conducting different clinical studies on how these factors impact PAD.

For example, in one study,"OMEGA-PAD", we are investigating the effects of omega-3 fatty acids (fish oil) in patients with PAD, looking more specifically at endothelial function and inflammation. In another study, the "OMEGA-Bedrest" study we are investigating the effects of physical inactivity on endothelial function, insulin resistance and inflammation, and are also testing a countermeasure (fish oil) for physical inactivity.

These clinical trials parallel research projects in my basic science laboratory studying how fatty acids influence the interactions between monocytes and endothelial cells, two cell lines critical to the development of atherosclerosis. We hope that these studies will help us understand how factors present in everyday life can impact the development of atherosclerotic disease in the lower extremities and how we can target specific therapies or lifestyle modification programs to help with this disease.


Adaptations to the gravitational mechanical unloading environment

What happens during spaceflight is not too different than when people lack physical exercise: the cardiovascular system becomes deconditioned. This part of my research program aims to draw parallels between what we can learn from astronauts flying in space and cardiovascular diseases on earth. Hence, we are conducting studies simulating the effects of microgravity on earth, specifically at the level of the organ ("physiological") and at the level of the cells ("cellular").


 

Melinda Schaller, M.D. 7/2015 - 6/2017
 
Most recent publications from a total of 57
  1. Schaller M, Zahner G, Gasper WJ, Harris WS, Conte MS, Hills NK, Grenon SM. . Relationship Between the Omega-3 Index and Specialized Pro-resolving Lipid Mediators in Patients with Peripheral Arterial Disease Taking Fish Oil Supplements. J Clin Lipid (in press). 2017. View in PubMed
  2. Drudi LM, Schaller MS, Hiramoto J, Gasper W, Harris WS, Hills NK, Grenon SM. Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease. J Surg Res. 2017 Apr; 210:124-131. View in PubMed
  3. Lindqvist D, Dhabhar FS, Mellon SH, Yehuda R, Grenon SM, Flory JD, Bierer LM, Abu-Amara D, Coy M, Makotkine I, Reus VI, Bersani FS, Marmar CR, Wolkowitz OM. Increased pro-inflammatory milieu in combat related PTSD - A new cohort replication study. Brain Behav Immun. 2016 Sep 13. View in PubMed
  4. Aschbacher K, Milush JM, Gilbert A, Almeida C, Sinclair E, Epling L, Grenon SM, Marco EJ, Puterman E, Epel E. Chronic stress is associated with reduced circulating hematopoietic progenitor cell number: A maternal caregiving model. Brain Behav Immun. 2016 Sep 10. View in PubMed
  5. Grenon SM, Owens CD, Alley H, Perez S, Whooley MA, Neylan TC, Aschbacher K, Gasper WJ, Hilton JF, Cohen BE. Posttraumatic Stress Disorder Is Associated With Worse Endothelial Function Among Veterans. J Am Heart Assoc. 2016; 5(3). View in PubMed
  6. Grenon SM, Owens CD, Nosova EV, Hughes-Fulford M, Alley HF, Chong K, Perez S, Yen PK, Boscardin J, Hellmann J, Spite M, Conte MS. Short-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid-Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial). J Am Heart Assoc. 2015 Aug; 4(8):e002034. View in PubMed
  7. Itoga NK, Woo K, Bismuth J, Bechara CF, Grenon M, Mitchell E, Zhou W. A Rising Generation of Diversity in the Vascular Surgery Workforce. Ann Vasc Surg. 2015 Oct; 29(7):1484-6. View in PubMed
  8. Nosova EV, Bartel K, Chong KC, Alley HF, Conte MS, Owens CD, Grenon SM. Analysis of nutritional habits and intake of polyunsaturated fatty acids in veterans with peripheral arterial disease. Vasc Med. 2015 Oct; 20(5):432-8. View in PubMed
  9. Chang TT, Spurlock SM, Candelario TL, Grenon SM, Hughes-Fulford M. Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines. FASEB J. 2015 Oct; 29(10):4122-32. View in PubMed
  10. Nosova EV, Conte MS, Grenon SM. Advancing beyond the "heart-healthy diet" for peripheral arterial disease. J Vasc Surg. 2015 Jan; 61(1):265-74. View in PubMed
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